The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy

Mutations in C9orf72 leading to hexanucleotide expansions are the most common genetic causes for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A phenotype resembling ALS and FTD is seen in transgenic mice overexpressing the hexanucleotide expansions, but is absent in C9orf72...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Ho, Wan Yun, Tai, Yee Kit, Chang, Jer-Cherng, Liang, Jason, Tyan, Sheue-Houy, Chen, Song, Guan, Jun-Lin, Zhou, Huilin, Shen, Han-Ming, Koo, Edward, Ling, Shuo-Chien
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526867/
https://ncbi.nlm.nih.gov/pubmed/30669939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1569441
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