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Systemic deregulation of autophagy upon loss of ALS- and FTD-linked C9orf72

A genetic mutation in the C9orf72 gene causes the most common forms of neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The C9orf72 protein, predicted to be a DENN-family protein, is reduced in ALS and FTD, but its functions remain poorly understood....

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Ji, Yon Ju, Ugolino, Janet, Brady, Nathan Ryan, Hamacher-Brady, Anne, Wang, Jiou
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529072/
https://ncbi.nlm.nih.gov/pubmed/28319438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1299312
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