Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress

The tumor suppressor TP53/p53 is a known regulator of apoptosis and macroautophagy/autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently incompatible processes remains unknown. We found that Drosophila lacking p53 displayed impaired autophagic flux, higher caspase activati...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Robin, Marion, Issa, Abdul Raouf, Santos, Cristiana C., Napoletano, Francesco, Petitgas, Céline, Chatelain, Gilles, Ruby, Mathilde, Walter, Ludivine, Birman, Serge, Domingos, Pedro M., Calvi, Brian R., Mollereau, Bertrand
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Research Paper - Basic Science
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526837/
https://ncbi.nlm.nih.gov/pubmed/30563404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1558001
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