Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes

Functional characterisation of different HIV-1 subtypes may improve understanding of viral pathogenesis and spread. Here, we evaluated the ability of 345 unique HIV-1 Nef clones representing subtypes A, B, C and D to inhibit NFAT signalling following TCR stimulation. The contribution of this Nef fun...

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Enregistré dans:
Détails bibliographiques
Publié dans:Virology
Auteurs principaux: Naidoo, Lisa, Mzobe, Zinhle, Jin, Steven W., Rajkoomar, Erasha, Reddy, Tarylee, Brockman, Mark A., Brumme, Zabrina L., Ndung’u, Thumbi, Mann, Jaclyn K.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526282/
https://ncbi.nlm.nih.gov/pubmed/30927712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.02.011
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