Expression of minor cartilage collagens and small leucine rich proteoglycans may be relatively reduced in osteoarthritic cartilage

BACKGROUND: In osteoarthritis (OA), cartilage matrix is lost despite vigorous chondrocyte anabolism. In this study, we attempted to determine whether altered matrix synthesis is involved in this paradox in disease progression through gene expression analysis and ultrastructural analysis of collagen...

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Bibliographic Details
Published in:BMC Musculoskelet Disord
Main Authors: Tanaka, Nobuho, Tashiro, Toshiyuki, Katsuragawa, Yozo, Sawabe, Motoji, Furukawa, Hiroshi, Fukui, Naoshi
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525975/
https://ncbi.nlm.nih.gov/pubmed/31103042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-019-2596-y
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