Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development

Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) development. However, recent work also shows that key molecular aspects of human END regulation differ even from rodents. Differentiation of human embryonic stem cells (ESCs) to END offers a tractable syste...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Rep
Hauptverfasser: Genga, Ryan M.J., Kernfeld, Eric M., Parsi, Krishna M., Parsons, Teagan J., Ziller, Michael J., Maehr, René
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525305/
https://ncbi.nlm.nih.gov/pubmed/30995470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.076
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