Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of Myeloid Zinc Finger-1 Serine 27 activates lysosome redistribution and invasion

HER2/ErbB2 activation turns on transcriptional processes that induce local invasion and lead to systemic metastasis. The early transcriptional changes needed for ErbB2-induced invasion are poorly understood. Here, we link ErbB2 activation to invasion via ErbB2-induced, SUMO-directed phosphorylation...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Brix, Ditte Marie, Tvingsholm, Siri Amanda, Hansen, Malene Bredahl, Clemmensen, Knut Bundgaard, Ohman, Tiina, Siino, Valentina, Lambrughi, Matteo, Hansen, Klaus, Puustinen, Pietri, Gromova, Irina, James, Peter, Papaleo, Elena, Varjosalo, Markku, Moreira, José, Jäättelä, Marja, Kallunki, Tuula
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525100/
https://ncbi.nlm.nih.gov/pubmed/30622337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0653-x
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