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Mechanism of 5′ splice site transfer for human spliceosome activation
The prespliceosome, comprising U1 and U2 snRNPs bound to the pre-mRNA 5′ splice site (5′SS) and branch point sequence, associates with the U4/U6.U5 tri-snRNP to form the fully-assembled precatalytic pre-B spliceosome. Here, we report cryo-EM structures of the human pre-B complex captured before U1 s...
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| Veröffentlicht in: | Science |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6525098/ https://ncbi.nlm.nih.gov/pubmed/30975767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax3289 |
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