Assessment of the impact of manufacturing changes on the physicochemical properties of the recombinant vaccine carrier ExoProtein A

Efforts to develop a vaccine for the elimination of malaria include the use of carrier proteins to assemble monomeric antigens into nanoparticles to maximize immunogenicity. Recombinant ExoProtein A (EPA) is a detoxified form of Pseudomonas aeruginosa Exotoxin A which has been used as a carrier in t...

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Dettagli Bibliografici
Pubblicato in:Vaccine
Autori principali: Burkhardt, Martin, Reiter, Karine, Nguyen, Vu, Suzuki, Motoshi, Herrera, Raul, Duffy, Patrick E., Shimp, Richard, MacDonald, Nicholas J., Olano, L. Renee, Narum, David L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525083/
https://ncbi.nlm.nih.gov/pubmed/30262247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2018.09.037
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