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Refactoring the cryptic streptophenazine biosynthetic gene cluster unites phenazine, polyketide, and nonribosomal peptide biochemistry

The disconnect between the genomic prediction of secondary metabolite biosynthetic potential and the observed laboratory production profile of microorganisms is well-documented. While heterologous expression of biosynthetic gene clusters (BGCs) is often seen as a potential solution to bridge this ga...

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Publicat a:Cell Chem Biol
Autors principals: Bauman, Katherine D., Li, Jie, Murata, Kazuya, Mantovani, Simone M., Dahesh, Samira, Nizet, Victor, Luhavaya, Hanna, Moore, Bradley S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525064/
https://ncbi.nlm.nih.gov/pubmed/30853419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.02.004
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