Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes

Nonribosomal peptides and polyketides are a diverse group of natural products with complex chemical structures and enormous pharmaceutical potential. They are synthesized on modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzyme complexes by a conserved thiotemplate mech...

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Bibliographic Details
Main Authors: Wang, Hao, Fewer, David P., Holm, Liisa, Rouhiainen, Leo, Sivonen, Kaarina
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078802/
https://ncbi.nlm.nih.gov/pubmed/24927540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401734111
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