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Refactoring the cryptic streptophenazine biosynthetic gene cluster unites phenazine, polyketide, and nonribosomal peptide biochemistry

The disconnect between the genomic prediction of secondary metabolite biosynthetic potential and the observed laboratory production profile of microorganisms is well-documented. While heterologous expression of biosynthetic gene clusters (BGCs) is often seen as a potential solution to bridge this ga...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Bauman, Katherine D., Li, Jie, Murata, Kazuya, Mantovani, Simone M., Dahesh, Samira, Nizet, Victor, Luhavaya, Hanna, Moore, Bradley S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525064/
https://ncbi.nlm.nih.gov/pubmed/30853419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.02.004
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