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Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

Recent developments in next-generation sequencing technologies have brought recognition of microbial genomes as a rich resource for novel natural product discovery. However, owing to the scarcity of efficient procedures to connect genes to molecules, only a small fraction of secondary metabolomes ha...

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Detalhes bibliográficos
Main Authors: Yamanaka, Kazuya, Reynolds, Kirk A., Kersten, Roland D., Ryan, Katherine S., Gonzalez, David J., Nizet, Victor, Dorrestein, Pieter C., Moore, Bradley S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918841/
https://ncbi.nlm.nih.gov/pubmed/24449899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319584111
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