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Analysis and Refactoring of the A-74528 Biosynthetic Pathway
A-74528 is a C-30 polyketide natural product that functions as an inhibitor of 2′,5′-oligoadenylate phosphodiesterase (2′-PDE), a key regulatory enzyme of the interferon pathway. Modulation of 2′-PDE represents a unique therapeutic approach to regulate viral infections. The gene cluster responsible...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3601660/ https://ncbi.nlm.nih.gov/pubmed/23442197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja311579s |
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