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Cloning, sequencing, heterologous expression and mechanistic analysis of A-74528 biosynthesis
A-74528 is a recently discovered natural product of Streptomyces sp. SANK 61196 that inhibits 2′,5′-oligoadenylate phosphodiesterase (2′-PDE), a key regulatory enzyme of the interferon pathway. Inhibition of 2′-PDE by A-74528 reduces viral replication, and therefore shows promise as a new type of an...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896501/ https://ncbi.nlm.nih.gov/pubmed/20550125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja102519v |
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