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Engineered Biosynthesis of the Antiparasitic Agent Frenolicin B and Rationally Designed Analogs in a Heterologous Host

The polyketide antibiotic frenolicin B harbors a biosynthetically intriguing benzoisochromanequinone core, and has been shown to exhibit promising antiparasitic activity against Eimeria tenella. To facilitate further exploration of its chemistry and biology, we constructed a biosynthetic route to fr...

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Detalhes bibliográficos
Main Authors: Fitzgerald, Jay T., Ridley, Christian P., Khosla, Chaitan
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245331/
https://ncbi.nlm.nih.gov/pubmed/21934692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ja.2011.86
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