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Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways

Organofluorines represent a rapidly expanding proportion of molecules used in pharmaceuticals, diagnostics, agrochemicals, and materials. Despite the prevalence of fluorine in synthetic compounds, the known biological scope is limited to a single pathway that produces fluoroacetate. Here, we demonst...

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Bibliografiske detaljer
Main Authors: Walker, Mark C., Thuronyi, Benjamin W., Charkoudian, Louise K., Lowry, Brian, Khosla, Chaitan, Chang, Michelle C. Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057101/
https://ncbi.nlm.nih.gov/pubmed/24009388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1242345
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