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Elucidating the mechanism of fluorinated extender unit loading for improved production of fluorine-containing polyketides

Polyketides are a large family of bioactive natural products synthesized by polyketide synthase (PKS) enzyme complexes predominantly from acetate and propionate. Given the structural diversity of compounds produced using these two simple building blocks, there has been longstanding interest in engin...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Ad, Omer, Thuronyi, Benjamin W., Chang, Michelle C. Y.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293041/
https://ncbi.nlm.nih.gov/pubmed/28096394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614196114
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