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Optimization of Drug Candidates that Inhibit the D-loop Activity of RAD51
RAD51 is the central protein in homologous recombination repair (HR), where it first binds ssDNA and then catalyzes strand invasion via a D-loop intermediate. Additionally, RAD51 plays a role in faithful DNA replication by protecting stalled replication forks; this requires RAD51 to bind DNA but may...
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| Publicado no: | ChemMedChem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6525040/ https://ncbi.nlm.nih.gov/pubmed/30957434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900075 |
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