RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

Homologous recombination serves multiple roles in DNA repair that are essential for maintaining genomic stability. We here describe RI-1, a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand a...

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Detalhes bibliográficos
Main Authors: Budke, Brian, Logan, Hillary L., Kalin, Jay H., Zelivianskaia, Anna S., Cameron McGuire, William, Miller, Luke L., Stark, Jeremy M., Kozikowski, Alan P., Bishop, Douglas K., Connell, Philip P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424541/
https://ncbi.nlm.nih.gov/pubmed/22573178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks353
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