Small molecule derived from a natural product that mitigates radiation injury

Por Connell, Philip P., Weichselbaum, Ralph R.
Publicado em 2013

Elevated Radiotherapy Toxicity in the Setting of Germline PTEN Mutation

Por Tatebe, Ken, Chmura, Steven J., Connell, Philip P.
Publicado no Pract Radiat Oncol (2019)

New paradigms and future challenges in Radiation Oncology: An Update of Biological Targets and Technology()

Por Liauw, Stanley L., Connell, Philip P., Weichselbaum, Ralph R.
Publicado em 2013

Retuning the Radio in Radiobiology

Por Chmura, Steven J, Connell, Philip P, Weichselbaum, Ralph R
Publicado no J Natl Cancer Inst (2017)

Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?

Por Budke, Brian, Lv, Wei, Kozikowski, Alan P., Connell, Philip P.
Publicado no ChemMedChem (2016)

Real-time solution measurement of RAD51- and RecA-mediated strand assimilation without background annealing

Por Budke, Brian, Chan, Yuen-Ling, Bishop, Douglas K., Connell, Philip P.
Publicado em 2013

Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51

Por Lv, Wei, Budke, Brian, Pawlowski, Michal, Connell, Philip P., Kozikowski, Alan P.
Publicado no J Med Chem (2016)

Optimization of Drug Candidates that Inhibit the D-loop Activity of RAD51

Por Budke, Brian, Tueckmantel, Werner, Miles, Kelsey, Kozikowski, Alan P., Connell, Philip P.
Publicado no ChemMedChem (2019)

Low Recombination Proficiency Score (RPS) predicts heightened sensitivity to DNA-damaging chemotherapy in breast cancer

Por Pitroda, Sean P., Bao, Riyue, Andrade, Jorge, Weichselbaum, Ralph R., Connell, Philip P.
Publicado no Clin Cancer Res (2017)

An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity

Por Budke, Brian, Kalin, Jay H., Pawlowski, Michal, Zelivianskaia, Anna S., Wu, Megan, Kozikowski, Alan P., Connell, Philip P.
Publicado em 2012

DNA Repair Pathway Gene Expression Score Correlates with Repair Proficiency and Tumor Sensitivity to Chemotherapy

Por Pitroda, Sean. P., Pashtan, Itai. M., Logan, Hillary. L., Budke, Brian, Darga, Thomas E., Weichselbaum, Ralph. R., Connell, Philip. P.
Publicado no Sci Transl Med (2014)

A chemical compound that stimulates the human homologous recombination protein RAD51

Por Jayathilaka, Krishanthi, Sheridan, Sean D., Bold, Tyler D., Bochenska, Katarzyna, Logan, Hillary L., Weichselbaum, Ralph R., Bishop, Douglas K., Connell, Philip P.
Publicado em 2008

The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors

Por Mason, Jennifer M, Logan, Hillary L., Budke, Brian, Wu, Megan, Pawlowski, Michal, Weichselbaum, Ralph R., Kozikowski, Alan P., Bishop, Douglas K., Connell, Philip P.
Publicado em 2014

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells

Por Mason, Jennifer M., Dusad, Kritika, Wright, William Douglass, Grubb, Jennifer, Budke, Brian, Heyer, Wolf-Dietrich, Connell, Philip P., Weichselbaum, Ralph R., Bishop, Douglas K.
Publicado no Nucleic Acids Res (2015)

Primary Tumor Necrosis Predicts Distant Control in Locally Advanced Soft Tissue Sarcomas Following Preoperative Concurrent Chemoradiotherapy

Por MacDermed, Dhara M., Miller, Luke L., Peabody, Terrance D., Simon, Michael A., Luu, Hue H., Haydon, Rex C., Montag, Anthony G., Undevia, Samir D., Connell, Philip P.
Publicado em 2009

RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

Por Budke, Brian, Logan, Hillary L., Kalin, Jay H., Zelivianskaia, Anna S., Cameron McGuire, William, Miller, Luke L., Stark, Jeremy M., Kozikowski, Alan P., Bishop, Douglas K., Connell, Philip P.
Publicado em 2012

Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma

Por Chlenski, Alexandre, Park, Chanyoung, Dobratic, Marija, Salwen, Helen R., Budke, Brian, Park, Jae-Hyun, Miller, Ryan, Applebaum, Mark A., Wilkinson, Emma, Nakamura, Yusuke, Connell, Philip P., Cohn, Susan L.
Publicado no Mol Cancer Ther (2019)