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An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity
Homologous recombination (HR) is an essential process in cells that provides repair of DNA double-strand breaks and lesions that block DNA replication. RAD51 is an evolutionarily conserved protein that is central to HR. Overexpression of RAD51 protein is common in cancer cells and represents a poten...
Gorde:
| Egile Nagusiak: | , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2012
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3619390/ https://ncbi.nlm.nih.gov/pubmed/23231413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301565b |
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