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Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat and human microsomes
As part of a program toward making analogues of amlexanox (1), currently under clinical investigation for the treatment of type 2 diabetes and obesity, we have synthesized derivative 5 in which deuterium has been introduced into two sites of metabolism on the C-7 isopropyl function of amlexanox. The...
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| Pubblicato in: | J Labelled Comp Radiopharm |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6525014/ https://ncbi.nlm.nih.gov/pubmed/30828860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3716 |
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