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Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

Direct conversion of human somatic fibroblasts into induced neurons (iNs) allows for the generation of functional neurons while bypassing any stem cell intermediary stages. Although iN technology has an enormous potential for modeling age-related diseases, as well as therapeutic approaches, the tech...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Herdy, Joseph, Schafer, Simon, Kim, Yongsung, Ansari, Zoya, Zangwill, Dina, Ku, Manching, Paquola, Apua, Lee, Hyungjun, Mertens, Jerome, Gage, Fred H
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524968/
https://ncbi.nlm.nih.gov/pubmed/31099332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41356
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