Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans

Reduced protein homeostasis leading to increased protein instability is a common molecular feature of aging, but it remains unclear whether this is a cause or consequence of the aging process. In neurodegenerative diseases and other amyloidoses, specific proteins self-assemble into amyloid fibrils a...

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Pubblicato in:eLife
Autori principali: Huang, Chaolie, Wagner-Valladolid, Sara, Stephens, Amberley D, Jung, Raimund, Poudel, Chetan, Sinnige, Tessa, Lechler, Marie C, Schlörit, Nicole, Lu, Meng, Laine, Romain F, Michel, Claire H, Vendruscolo, Michele, Kaminski, Clemens F, Kaminski Schierle, Gabriele S, David, Della C
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524967/
https://ncbi.nlm.nih.gov/pubmed/31050339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43059
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