Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans

Reduced protein homeostasis leading to increased protein instability is a common molecular feature of aging, but it remains unclear whether this is a cause or consequence of the aging process. In neurodegenerative diseases and other amyloidoses, specific proteins self-assemble into amyloid fibrils a...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Huang, Chaolie, Wagner-Valladolid, Sara, Stephens, Amberley D, Jung, Raimund, Poudel, Chetan, Sinnige, Tessa, Lechler, Marie C, Schlörit, Nicole, Lu, Meng, Laine, Romain F, Michel, Claire H, Vendruscolo, Michele, Kaminski, Clemens F, Kaminski Schierle, Gabriele S, David, Della C
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524967/
https://ncbi.nlm.nih.gov/pubmed/31050339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43059
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