Emicizumab, A Bispecific Antibody to Factors IX/IXa and X/Xa, Does Not Interfere with Antithrombin or TFPI Activity In Vitro

Emicizumab is a humanized bispecific antibody that binds simultaneously to factor (F) IXa and FX replacing the cofactor function of FVIIIa. Because emicizumab recognizes FIX/FIXa and FX/FXa, a question may arise whether emicizumab competes with antithrombin (AT) and/or tissue factor pathway inhibito...

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Detalhes bibliográficos
Publicado no:TH Open
Main Authors: Noguchi-Sasaki, Mariko, Soeda, Tetsuhiro, Ueyama, Atsunori, Muto, Atsushi, Hirata, Michinori, Kitamura, Hidetomo, Fujimoto-Ouchi, Kaori, Kawabe, Yoshiki, Nogami, Keiji, Shima, Midori, Kitazawa, Takehisa
Formato: Artigo
Idioma:Inglês
Publicado em: Georg Thieme Verlag KG 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524866/
https://ncbi.nlm.nih.gov/pubmed/31249933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0038-1636538
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