Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A

ACE910 is a humanized anti-factor IXa/X bispecific antibody mimicking the function of factor VIII (FVIII). We previously demonstrated in nonhuman primates that a single IV dose of ACE910 exerted hemostatic activity against hemophilic bleeds artificially induced in muscles and subcutis, and that a su...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Muto, Atsushi, Yoshihashi, Kazutaka, Takeda, Minako, Kitazawa, Takehisa, Soeda, Tetsuhiro, Igawa, Tomoyuki, Sampei, Zenjiro, Kuramochi, Taichi, Sakamoto, Akihisa, Haraya, Kenta, Adachi, Kenji, Kawabe, Yoshiki, Nogami, Keiji, Shima, Midori, Hattori, Kunihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231424/
https://ncbi.nlm.nih.gov/pubmed/25274508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-585737
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