Non–antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity

While antibody engineering improves the properties of therapeutic antibodies, optimization of regions that do not contact antigens has been mainly focused on modifying the effector functions and pharmacokinetics of antibodies. We recently reported an asymmetric anti-FIXa/FX bispecific IgG(4) antibod...

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Bibliografski detalji
Izdano u:MAbs
Glavni autori: Sampei, Zenjiro, Igawa, Tomoyuki, Soeda, Tetsuhiro, Funaki, Miho, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Muto, Atsushi, Kojima, Tetsuo, Nakamura, Satoshi, Hattori, Kunihiro
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2014
Teme:
Reports
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622617/
https://ncbi.nlm.nih.gov/pubmed/25524207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19420862.2015.989028
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