Non–antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity

While antibody engineering improves the properties of therapeutic antibodies, optimization of regions that do not contact antigens has been mainly focused on modifying the effector functions and pharmacokinetics of antibodies. We recently reported an asymmetric anti-FIXa/FX bispecific IgG(4) antibod...

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Détails bibliographiques
Publié dans:MAbs
Auteurs principaux: Sampei, Zenjiro, Igawa, Tomoyuki, Soeda, Tetsuhiro, Funaki, Miho, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Muto, Atsushi, Kojima, Tetsuo, Nakamura, Satoshi, Hattori, Kunihiro
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2014
Sujets:
Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622617/
https://ncbi.nlm.nih.gov/pubmed/25524207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19420862.2015.989028
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