TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

Mutations in or dys-regulation of the TDP-43 gene have been associated with TDP-43 proteinopathy, a spectrum of neurodegenerative diseases including Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS). The underlying molecular and cellular defects, however, remain unclea...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Wang, Peng, Deng, Jianwen, Dong, Jie, Liu, Jianghong, Bigio, Eileen H., Mesulam, Marsel, Wang, Tao, Sun, Lei, Wang, Li, Lee, Alan Yueh-Luen, McGee, Warren A., Chen, Xiaoping, Fushimi, Kazuo, Zhu, Li, Wu, Jane Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524796/
https://ncbi.nlm.nih.gov/pubmed/31100073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007947
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