Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

The maintenance of genomic integrity is essential for normal cellular functions. However, it is difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA damage increases with age and is exacerbated by multiple neurological disorders, including Alzheimer’s disease (AD)...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol Commun
Autors principals: Shanbhag, Niraj M., Evans, Mark D., Mao, Wenjie, Nana, Alissa L., Seeley, William W., Adame, Anthony, Rissman, Robert A., Masliah, Eliezer, Mucke, Lennart
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524256/
https://ncbi.nlm.nih.gov/pubmed/31101070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0723-5
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