An ATM-Dependent Transcriptional Silencing Program is Transmitted Through Chromatin in Cis to DNA Double Strand Breaks

DNA double strand breaks (DSBs) initiate extensive local and global alterations in chromatin structure, many of which depend on the ATM kinase. Histone H2A ubiquitylation (uH2A) on chromatin surrounding DSBs is one example, thought to be important for recruitment of repair proteins. uH2A is also imp...

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Autori principali: Shanbhag, Niraj M., Rafalska-Metcalf, Ilona U., Balane-Bolivar, Carlo, Janicki, Susan M., Greenberg, Roger A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920610/
https://ncbi.nlm.nih.gov/pubmed/20550933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.04.038
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