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Thiol-reactive bifunctional chelators for the creation of site-selectively modified radioimmunoconjugates with improved stability
Maleimide-bearing bifunctional chelators have been used extensively for the site-selective bioconjugation and radiolabeling of peptides and proteins. However, bioconjugates obtained using these constructs inevitably suffer from limited stability in vivo, a trait which translates into suboptimal acti...
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| Publié dans: | Bioconjug Chem |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6523022/ https://ncbi.nlm.nih.gov/pubmed/29509393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.8b00081 |
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