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Thiol-reactive bifunctional chelators for the creation of site-selectively modified radioimmunoconjugates with improved stability

Maleimide-bearing bifunctional chelators have been used extensively for the site-selective bioconjugation and radiolabeling of peptides and proteins. However, bioconjugates obtained using these constructs inevitably suffer from limited stability in vivo, a trait which translates into suboptimal acti...

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Bibliografiske detaljer
Udgivet i:Bioconjug Chem
Main Authors: Adumeau, Pierre, Davydova, Maria, Zeglis, Brian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523022/
https://ncbi.nlm.nih.gov/pubmed/29509393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.8b00081
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