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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates

Maleimide-bearing bifunctional probes have been employed for decades for the site-selective modification of thiols in biomolecules, especially antibodies. Yet maleimide-based conjugates display limited stability in vivo because the succinimidyl thioether linkage can undergo a retro-Michael reaction....

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Détails bibliographiques
Publié dans:J Vis Exp
Auteurs principaux: Davydova, Maria, Le Roi, Guillaume Dewaele, Adumeau, Pierre, Zeglis, Brian M.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7169956/
https://ncbi.nlm.nih.gov/pubmed/30907883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/59063
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