Nalaganje...
Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Maleimide-bearing bifunctional probes have been employed for decades for the site-selective modification of thiols in biomolecules, especially antibodies. Yet maleimide-based conjugates display limited stability in vivo because the succinimidyl thioether linkage can undergo a retro-Michael reaction....
Shranjeno v:
| izdano v: | J Vis Exp |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7169956/ https://ncbi.nlm.nih.gov/pubmed/30907883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/59063 |
| Oznake: |
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