Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

Although promoter-associated CpG islands have been established as targets of DNA methylation changes in cancer, previous studies suggest that epigenetic dysregulation outside the promoter region may be more closely associated with transcriptional changes. Here we examine DNA methylation, chromatin m...

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Wydane w:Nat Commun
Główni autorzy: Ando, Mizuo, Saito, Yuki, Xu, Guorong, Bui, Nam Q., Medetgul-Ernar, Kate, Pu, Minya, Fisch, Kathleen, Ren, Shuling, Sakai, Akihiro, Fukusumi, Takahito, Liu, Chao, Haft, Sunny, Pang, John, Mark, Adam, Gaykalova, Daria A., Guo, Theresa, Favorov, Alexander V., Yegnasubramanian, Srinivasan, Fertig, Elana J., Ha, Patrick, Tamayo, Pablo, Yamasoba, Tatsuya, Ideker, Trey, Messer, Karen, Califano, Joseph A.
Format: Artigo
Język:Inglês
Wydane: Nature Publishing Group UK 2019
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522544/
https://ncbi.nlm.nih.gov/pubmed/31097695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09937-w
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