MDH1 and MPP7 regulate autophagy in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is driven by metabolic changes in pancreatic cells caused by oncogenic mutations and dysregulation of p53. PDAC cell lines and PDAC-derived xenografts grow as a result of altered metabolic pathways, changes in stroma, and autophagy. Selective targeting and inh...

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Pubblicato in:Cancer Res
Autori principali: New, Maria, Van Acker, Tim, Sakamaki, Jun-ichi, Jiang, Ming, Saunders, Rebecca E., Long, Jaclyn, Wang, Victoria M.-Y., Behrens, Axel, Cerveira, Joana, Sudhakar, Padhmanand, Korcsmaros, Tamas, Jefferies, Harold B. J., Ryan, Kevin M., Howell, Michael, Tooze, Sharon A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522344/
https://ncbi.nlm.nih.gov/pubmed/30765601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2553
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