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Inhibition of γ-Glutamyl Transpeptidase or Cysteine S-Conjugate β-Lyase Activity Blocks the Nephrotoxicity of Cisplatin in Mice
Cisplatin is nephrotoxic. The mechanism underlying this organ-specific toxicity is unknown. We hypothesize that cisplatin is metabolized via a γ-glutamyl transpeptidase (GGT) and cysteine S-conjugate β-lyase-dependent pathway that has been shown to activate several haloalkenes to nephrotoxins. To te...
Gorde:
| Argitaratua izan da: | J Pharmacol Exp Ther |
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| Egile Nagusiak: | , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2002
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6522257/ https://ncbi.nlm.nih.gov/pubmed/11752109 |
| Etiketak: |
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