Pathogen blockade of TAK1 triggers caspase-8 dependent cleavage of Gasdermin D and cell death

Limited proteolysis of Gasdermin D (GSDMD) generates an N-terminal pore-forming fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome-activated caspase-1 or −11. It is currently unknown if macrophage GSDMD can be processed by other mechanisms. Here we describe an addi...

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Bibliographic Details
Published in:Science
Main Authors: Orning, Pontus, Weng, Dan, Starheim, Kristian, Ratner, Dmitry, Best, Zachary, Lee, Bettina, Brooks, Alexandria, Xia, Shiyu, Wu, Hao, Kelliher, Michelle A., Berger, Scott B., Gough, Peter J., Bertin, John, Proulx, Megan M., Goguen, Jon D., Kayagaki, Nobuhiko, Fitzgerald, Katherine A., Lien, Egil
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522129/
https://ncbi.nlm.nih.gov/pubmed/30361383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau2818
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