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Noninvasive Imaging and Quantification of Radiotherapy-Induced PD-L1 Upregulation with (89)Zr–Df–Atezolizumab

Immune checkpoint expression is highly dynamic, and combination treatments including radiotherapy can particularly modulate this expression. PET imaging using (89)Zr–Df–atezolizumab can provide insight into the levels of PD-L1 variation following radiotherapy treatments. In vitro screening was used...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Bioconjug Chem
Hauptverfasser: Ehlerding, Emily B., Lee, Hye Jin, Barnhart, Todd E., Jiang, Dawei, Kang, Lei, McNeel, Douglas G., Engle, Jonathan W., Cai, Weibo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521689/
https://ncbi.nlm.nih.gov/pubmed/30973703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.9b00178
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