α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin

Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on α7...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Cao, Mingju, MacDonald, James W., Liu, Hai L., Weaver, Molly, Cortes, Marina, Durosier, Lucien D., Burns, Patrick, Fecteau, Gilles, Desrochers, André, Schulkin, Jay, Antonelli, Marta C., Bernier, Raphael A., Dorschner, Michael, Bammler, Theo K., Frasch, Martin G.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520997/
https://ncbi.nlm.nih.gov/pubmed/31143190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01063
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