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Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses. This compound is currently under clinical development for the treatment of Ebola virus disease (EVD). While antiviral effects have been demon...

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Bibliografiske detaljer
Udgivet i:Viruses
Main Authors: Tchesnokov, Egor P., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520719/
https://ncbi.nlm.nih.gov/pubmed/30987343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v11040326
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