Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase (RdRp), which is the likely target of...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Gordon, Calvin J., Tchesnokov, Egor P., Woolner, Emma, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242698/
https://ncbi.nlm.nih.gov/pubmed/32284326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013679
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