Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

The major genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a C9orf72 G(4)C(2) repeat expansion(1,2). Proposed mechanisms by which the expansion causes c9FTD/ALS include toxicity from repeat-containing RNA and from dipeptide repeat proteins translated from the...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nat Med
Главные авторы: Zhang, Yong-Jie, Gendron, Tania F., Ebbert, Mark T. W., O′Raw, Aliesha D., Yue, Mei, Jansen-West, Karen, Zhang, Xu, Prudencio, Mercedes, Chew, Jeannie, Cook, Casey N., Daughrity, Lillian M., Tong, Jimei, Song, Yuping, Pickles, Sarah R., Castanedes-Casey, Monica, Kurti, Aishe, Rademakers, Rosa, Oskarsson, Bjorn, Dickson, Dennis W., Hu, Wenqian, Gitler, Aaron D., Fryer, John D., Petrucelli, Leonard
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520050/
https://ncbi.nlm.nih.gov/pubmed/29942091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0071-1
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы