Affinity maturation of the anti-citrullinated protein antibody paratope drives epitope spreading and polyreactivity in rheumatoid arthritis

OBJECTIVES: Anti-citrullinated protein antibodies (ACPA) are a hallmark of rheumatoid arthritis (RA). While epitope spreading of the serum ACPA response is believed to contribute to RA pathogenesis, little is understood regarding how this phenomenon occurs. We analyzed the antibody repertoires of in...

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Bibliographic Details
Published in:Arthritis Rheumatol
Main Authors: Kongpachith, Sarah, Lingampalli, Nithya, Ju, Chia-Hsin, Blum, Lisa K., Lu, Daniel R., Elliott, Serra E., Mao, Rong, Robinson, William H.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519961/
https://ncbi.nlm.nih.gov/pubmed/30811898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40760
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