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Affinity maturation of the anti-citrullinated protein antibody paratope drives epitope spreading and polyreactivity in rheumatoid arthritis
OBJECTIVES: Anti-citrullinated protein antibodies (ACPA) are a hallmark of rheumatoid arthritis (RA). While epitope spreading of the serum ACPA response is believed to contribute to RA pathogenesis, little is understood regarding how this phenomenon occurs. We analyzed the antibody repertoires of in...
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| Publicado no: | Arthritis Rheumatol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6519961/ https://ncbi.nlm.nih.gov/pubmed/30811898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40760 |
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