Affinity maturation of the anti-citrullinated protein antibody paratope drives epitope spreading and polyreactivity in rheumatoid arthritis

OBJECTIVES: Anti-citrullinated protein antibodies (ACPA) are a hallmark of rheumatoid arthritis (RA). While epitope spreading of the serum ACPA response is believed to contribute to RA pathogenesis, little is understood regarding how this phenomenon occurs. We analyzed the antibody repertoires of in...

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Gepubliceerd in:Arthritis Rheumatol
Hoofdauteurs: Kongpachith, Sarah, Lingampalli, Nithya, Ju, Chia-Hsin, Blum, Lisa K., Lu, Daniel R., Elliott, Serra E., Mao, Rong, Robinson, William H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519961/
https://ncbi.nlm.nih.gov/pubmed/30811898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40760
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