Rapid and reproducible characterization of sickling during automated deoxygenation in sickle cell disease patients

In sickle cell disease (SCD), sickle hemoglobin (HbS) polymerizes upon deoxygenation, resulting in sickling of red blood cells (RBCs). These sickled RBCs have strongly reduced deformability, leading to vaso‐occlusive crises and chronic hemolytic anemia. To date, there are no reliable laboratory para...

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Detaylı Bibliyografya
Yayımlandı:Am J Hematol
Asıl Yazarlar: Rab, Minke A.E., van Oirschot, Brigitte A., Bos, Jennifer, Merkx, Tesy H., van Wesel, Annet C.W., Abdulmalik, Osheiza, Safo, Martin K., Versluijs, Birgitta A., Houwing, Maite E., Cnossen, Marjon H., Riedl, Jurgen, Schutgens, Roger E.G., Pasterkamp, Gerard, Bartels, Marije, van Beers, Eduard J., van Wijk, Richard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley & Sons, Inc. 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518936/
https://ncbi.nlm.nih.gov/pubmed/30784099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.25443
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