Laddar...
New Developments in Anti-Sickling Agents: Can Drugs Directly Prevent the Polymerization of Sickle Haemoglobin In Vivo?
The hallmark of sickle cell disease is the polymerization of sickle haemoglobin due to a point mutation in the β-globin gene (HBB). Under low oxygen saturation, sickle haemoglobin assumes the tense (T-state) deoxygenated conformation that can form polymers, leading to rigid erythrocytes with impaire...
Sparad:
| I publikationen: | Br J Haematol |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2016
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035193/ https://ncbi.nlm.nih.gov/pubmed/27605087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14264 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|