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Substrate stiffness-dependent regulation of the SRF−Mkl1 co-activator complex requires the inner nuclear membrane protein Emerin

The complex comprising serum response factor (SRF) and megakaryoblastic leukemia 1 protein (Mkl1) promotes myofibroblast differentiation during wound healing. SRF−Mkl1 is sensitive to the mechanical properties of the extracellular environment; but how cells sense and transduce mechanical cues to mod...

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Bibliografische gegevens
Gepubliceerd in:J Cell Sci
Hoofdauteurs: Willer, Margaret K., Carroll, Christopher W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists Ltd 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518328/
https://ncbi.nlm.nih.gov/pubmed/28576971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.197517
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